SMIMS was started in 2001, with its first batch of MBBS students joining on 10 October, 2001. SMIMS was started as a joint venture between the Sikkim government and the Manipal group.
Apart from MBBS, the college also awards degrees in paramedical courses like BPT., MSC., BSC nursing and DMLT in medical fields. The first batch consisted of 100 students, which however came down to 50 from the 4th batch. It has now been recognised by the Medical Council of India. DNB courses in Surgery, Obstetrics-&-Gynaecology, Medicine, Paediatrics & Ophthalmology are available (PG courses).
The Central Referral Hospital and Sir Thutob Namgyal Memorial (STNM) Hospitals are used for clinical training/teaching. There are five lecture halls in the CRH building and four in the new College building. There is an auditorium in the new College building, with a sitting capacity of approximately 750 people.