Sydenham College of Commerce & Economics was set up in 1913 at the initiative of Mr. K. Subramani Aiyer, Sir Dinshaw Vachha, Sir Manmohandas Ramji and Lord Sydenham who was the then Governor of Bombay. It was named after Lord Sydenham as the college received a handsome donation of Rs. 1,85,000 from the Lord Sydenham Memorial Committee. The staff at Sydenham College of Commerce and Economics comprises of 41 teaching members and 37 non-teaching members. Students at the Sydenham College of Commerce and Economics get enough opportunities for engaging themselves in co- curricular and extra curricular activities.